Traceless petasis reaction

The Petasis reaction (alternatively called the Petasis borono–Mannich (PBM) reaction) is the multi-component reaction of an amine, a carbonyl, and a vinyl- or aryl-boronic acid to form substituted amines. Reported in 1993 by Nicos Petasis as a practical method towards the synthesis of a geometrically pure antifungal agent, naftifine.

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European Journal of Organic Chemistry: Vol 2020, No 24

Petasis reaction Petasis reaction The Petasis reaction is the chemical reaction of an amine , aldehyde , and vinyl - or aryl - boronic acid to form substituted amines. [ cite journal | author = Petasis, N. A.; Akritopoulou, I. | journal = Tetrahedron Lett. SAMDI Mass Spectrometry-Enabled High-Throughput SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction Authors: Diagne AB, Li S, Perkowski GA, Mrksich M, Thomson RJ ACS Comb Sci., 2015 Nov 9;17(11):658-62 View Resource

SCOTT E. SCHAUS - Boston University

High throughput analysis enables high throughput